The Marshall House is one of the key structures in the North Milford Historic District. This District includes a number of Milford's oldest buildings. Most of the buildings in the District were constructed before 1860. According to the Historic survey this has "the finest collection of homes in Milford." There have been little significant intrusions of modern buildings in the area. Like many of the original buildings on this street, the Marshall House has historically been used for both business and residence.

The Marshall House was originally constructed as two separate buildings. John Law, a brick mason, purchased the property on January 10, 1787. It was one of the original lots sold by Milford co-founder, Joseph Oliver. Laws constructed a two and a half  story, three bay, gable roof brick structure that is today the east front section of the house. Eventually ownership of the house passed to Louder Layton in 1806. He then built an adjacent house to the original structure. It originally served as a store but became Milford's first bank in 1821. The bank closed in 1827.

In 1879 Mr. Andrew Donnell purchased both houses for his daughter Mary Louise Marshall and her husband Dr. George William Marshall. The two adjacent buildings were remodeled to create one house and extensive interior and exterior renovations were made.  Dr. Marshall used the building as his residence and doctor's office until his death in 1915.

The Marshall family played a critical role in the establishment of the Milford Hospital located here in 1917. It was closed during World War I and reopened at 110 NW Front St in 1923 under the name of the Marshall Hospital.

 Standing on the banks of the Mispillion River adjacent to Milford's new Riverwalk, the Marshall House is a prominent historical landmark.